Genetic drivers of vulnerability and resistance in relapsed acute lymphoblastic leukemia

by Lu, Sydney X., Abdel-Wahab, Omar
Published in Proc Natl Acad Sci U S A (2016)

Relapse After Allogeneic Hematopoietic Cell Therapy

by van den Brink, Marcel R.M., Porter, David L., Giralt, Sergio, Lu, Sydney X., Jenq, Robert R., Hanash, Alan, Bishop, Michael R.
Published 2009

Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity

by Borsotti, Chiara, Franklin, Anna R. K., Lu, Sydney X., Kim, Theo D., Smith, Odette M., Suh, David, King, Chris G., Chow, Andrew, Liu, Chen, Alpdogan, Onder, van den Brink, Marcel R. M.
Published 2007

Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease

by Rotolo, Jimmy A., Stancevic, Branka, Lu, Sydney X., Zhang, Jianjun, Suh, David, King, Christopher G., Kappel, Lucy W., Murphy, George F., Liu, Chen, Fuks, Zvi, van den Brink, Marcel R., Kolesnick, Richard
Published 2009

Rapidly proliferating CD44(hi) peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation

by Alpdogan, S. Önder, Lu, Sydney X., Patel, Neel, McGoldrick, Suzanne, Suh, David, Budak-Alpdogan, Tulin, Smith, Odette M., Grubin, Jeremy, King, Christopher, Goldberg, Gabrielle L., Hubbard, Vanessa M., Kochman, Adam A., van den Brink, Marcel R. M.
Published 2008

Absence of β7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine

by Waldman, Elisha, Lu, Sydney X., Hubbard, Vanessa M., Kochman, Adam A., Eng, Jeffrey M., Terwey, Theis H., Muriglan, Stephanie J., Kim, Theo D., Heller, Glenn, Murphy, George F., Liu, Chen, Alpdogan, Onder, van den Brink, Marcel R. M.
Published 2006

NOD2 regulates hematopoietic cell function during graft-versus-host disease

by Penack, Olaf, Smith, Odette M., Cunningham-Bussel, Amy, Liu, Xin, Rao, Uttam, Yim, Nury, Na, Il-Kang, Holland, Amanda M., Ghosh, Arnab, Lu, Sydney X., Jenq, Robert R., Liu, Chen, Murphy, George F., Brandl, Katharina, van den Brink, Marcel R.M.
Published 2009

Targeting an RNA-binding Protein Network in Acute Myeloid Leukemia

by Wang, Eric, Lu, Sydney X., Pastore, Alessandro, Chen, Xufeng, Imig, Jochen, Lee, Stanley Chun-Wei, Hockemeyer, Kathryn, Ghebrechristos, Yohana E., Yoshimi, Akihide, Inoue, Daichi, Ki, Michelle, Cho, Hana, Bitner, Lillian, Kloetgen, Andreas, Lin, Kuan-Ting, Uehara, Taisuke, Owa, Takashi, Tibes, Raoul, Krainer, Adrian R., Abdel-Wahab, Omar, Aifantis, Iannis
Published in Cancer Cell (2019)

Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

by Landgren, Ola, Hofmann, Jonathan N., McShane, Charlene M., Santo, Loredana, Hultcrantz, Malin, Korde, Neha, Mailankody, Sham, Kazandjian, Dickran, Murata, Kazunori, Thoren, Katie, Ramanathan, Lakshmi, Dogan, Ahmet, Rustad, Even, Lu, Sydney X., Akhlaghi, Theresia, Kristinsson, Sigurdur Y., Björkholm, Magnus, Devlin, Sean, Purdue, Mark P., Pfeiffer, Ruth M., Turesson, Ingemar
Published in JAMA Oncol (2019)

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

by Lu, Sydney X., Alpdogan, Onder, Lin, Janine, Balderas, Robert, Campos-Gonzalez, Roberto, Wang, Xiao, Gao, Guo-Jian, Suh, David, King, Christopher, Chow, Melanie, Smith, Odette M., Hubbard, Vanessa M., Bautista, Johanne L., Cabrera-Perez, Javier, Zakrzewski, Johannes L., Kochman, Adam A., Chow, Andrew, Altan-Bonnet, Gregoire, van den Brink, Marcel R. M.
Published 2008

Inhibition of Neovascularization to Simultaneously Ameliorate Graft-vs-Host Disease and Decrease Tumor Growth

by Penack, Olaf, Henke, Erik, Suh, David, King, Chris G., Smith, Odette M., Na, Il-Kang, Holland, Amanda M., Ghosh, Arnab, Lu, Sydney X., Jenq, Robert R., Liu, Chen, Murphy, George F., Lu, Theresa T., May, Chad, Scheinberg, David A., Gao, Ding Cheng, Mittal, Vivek, Heller, Glenn, Benezra, Robert, van den Brink, Marcel R. M.
Published 2010

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

by Durham, Benjamin H., Getta, Bartlomiej, Dietrich, Sascha, Taylor, Justin, Won, Helen, Bogenberger, James M., Scott, Sasinya, Kim, Eunhee, Chung, Young Rock, Chung, Stephen S., Hüllein, Jennifer, Walther, Tatjana, Wang, Lu, Lu, Sydney X., Oakes, Christopher C., Tibes, Raoul, Haferlach, Torsten, Taylor, Barry S., Tallman, Martin S., Berger, Michael F., Park, Jae H., Zenz, Thorsten, Abdel-Wahab, Omar
Published in Blood (2017)

Spliceosomal disruption of the non-canonical BAF complex in cancer

by Inoue, Daichi, Chew, Guo-Liang, Liu, Bo, Michel, Brittany C., Pangallo, Joseph, D’Avino, Andrew R., Hitchman, Tyler, North, Khrystyna, Lee, Stanley Chun-Wei, Bitner, Lillian, Block, Ariele, Moore, Amanda R., Yoshimi, Akihide, Escobar-Hoyos, Luisa, Cho, Hana, Penson, Alex, Lu, Sydney X., Taylor, Justin, Chen, Yu, Kadoch, Cigall, Abdel-Wahab, Omar, Bradley, Robert K.
Published in Nature (2019)

Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation

by Jenq, Robert R., King, Christopher G., Volk, Christine, Suh, David, Smith, Odette M., Rao, Uttam K., Yim, Nury L., Holland, Amanda M., Lu, Sydney X., Zakrzewski, Johannes L., Goldberg, Gabrielle L., Diab, Adi, Alpdogan, Onder, Penack, Olaf, Na, Il-Kang, Kappel, Lucy W., Wolchok, Jedd D., Houghton, Alan N., Perales, Miguel-Angel, van den Brink, Marcel R. M.
Published 2009

Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

by Zakrzewski, Johannes L, Suh, David, Markley, John C, Smith, Odette M, King, Christopher, Goldberg, Gabrielle L, Jenq, Robert, Holland, Amanda M, Grubin, Jeremy, Cabrera-Perez, Javier, Brentjens, Renier J, Lu, Sydney X, Rizzuto, Gabrielle, Sant’Angelo, Derek B, Riviere, Isabelle, Sadelain, Michel, Heller, Glenn, Zúñiga-Pflücker, Juan Carlos, Lu, Chen, van den Brink, Marcel R M
Published 2008

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease

by Na, Il-Kang, Lu, Sydney X., Yim, Nury L., Goldberg, Gabrielle L., Tsai, Jennifer, Rao, Uttam, Smith, Odette M., King, Christopher G., Suh, David, Hirschhorn-Cymerman, Daniel, Palomba, Lia, Penack, Olaf, Holland, Amanda M., Jenq, Robert R., Ghosh, Arnab, Tran, Hien, Merghoub, Taha, Liu, Chen, Sempowski, Gregory D., Ventevogel, Melissa, Beauchemin, Nicole, van den Brink, Marcel R.M.
Published 2009

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

by Pastore, Alessandro, Gaiti, Federico, Lu, Sydney X., Brand, Ryan M., Kulm, Scott, Chaligne, Ronan, Gu, Hongcang, Huang, Kevin Y., Stamenova, Elena K., Béguelin, Wendy, Jiang, Yanwen, Schulman, Rafael C., Kim, Kyu-Tae, Alonso, Alicia, Allan, John N., Furman, Richard R., Gnirke, Andreas, Wu, Catherine J., Melnick, Ari M., Meissner, Alexander, Bernstein, Bradley E., Abdel-Wahab, Omar, Landau, Dan A.
Published in Nat Commun (2019)

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

by Yoshimi, Akihide, Balasis, Maria E., Vedder, Alexis, Feldman, Kira, Ma, Yan, Zhang, Hailing, Lee, Stanley Chun-Wei, Letson, Christopher, Niyongere, Sandrine, Lu, Sydney X., Ball, Markus, Taylor, Justin, Zhang, Qing, Zhao, Yulong, Youssef, Salma, Chung, Young Rock, Zhang, Xiao Jing, Durham, Benjamin H., Yang, Wendy, List, Alan F., Loh, Mignon L., Klimek, Virginia, Berger, Michael F., Stieglitz, Elliot, Padron, Eric, Abdel-Wahab, Omar
Published in Blood (2017)

Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation

by Lu, Sydney X., Kappel, Lucy W., Charbonneau-Allard, Anne-Marie, Atallah, Renée, Holland, Amanda M., Turbide, Claire, Hubbard, Vanessa M., Rotolo, Jimmy A., Smith, Marsinay, Suh, David, King, Christopher, Rao, Uttam K., Yim, Nury, Bautista, Johanne L., Jenq, Robert R., Penack, Olaf, Na, Il-Kang, Liu, Chen, Murphy, George, Alpdogan, Onder, Blumberg, Richard S., Macian, Fernando, Holmes, Kathryn V., Beauchemin, Nicole, van den Brink, Marcel R. M.
Published 2011

Absence of P-selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host-Disease

by Lu, Sydney X., Holland, Amanda M., Na, Il-Kang, Terwey, Theis H., Alpdogan, Onder, Bautista, Jhoanne L., Smith, Odette M., Suh, David, King, Christopher, Kochman, Adam, Hubbard, Vanessa M., Rao, Uttam K., Yim, Nury, Liu, Chen, Laga, Alvaro C., Murphy, George, Jenq, Robert, Zakrzewski, Johannes L., Penack, Olaf, Dykstra, Lindsay, Bampoe, Kevin, Perez, Lia, Furie, Bruce, Furie, Barbara, van den Brink, Marcel R.M.
Published 2010