Targeting an RNA-binding Protein Network in Acute Myeloid Leukemia

RNA-binding proteins (RBPs) are essential modulators of transcription and translation frequently dysregulated in cancer. We systematically interrogated RBP dependencies in human cancers using a comprehensive CRISPR/Cas9 domain-focused screen targeting RNA-binding domains of 490 classical RBPs. This...

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Udgivet i:Cancer Cell
Main Authors: Wang, Eric, Lu, Sydney X., Pastore, Alessandro, Chen, Xufeng, Imig, Jochen, Lee, Stanley Chun-Wei, Hockemeyer, Kathryn, Ghebrechristos, Yohana E., Yoshimi, Akihide, Inoue, Daichi, Ki, Michelle, Cho, Hana, Bitner, Lillian, Kloetgen, Andreas, Lin, Kuan-Ting, Uehara, Taisuke, Owa, Takashi, Tibes, Raoul, Krainer, Adrian R., Abdel-Wahab, Omar, Aifantis, Iannis
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424627/
https://ncbi.nlm.nih.gov/pubmed/30799057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.010
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