Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses

NF-κB plays a variety of roles in oncogenesis and immunity that may be beneficial for therapeutic targeting, but strategies to selectively inhibit NF-κB to exert antitumor activity have been elusive. Here we describe IT-901, a bioactive naphthalenethiobarbiturate derivative that potently inhibits th...

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Publicado no:Cancer Res
Main Authors: Shono, Yusuke, Tuckett, Andrea Z., Liou, Hsiou-Chi, Doubrovina, Ekaterina, Derenzini, Enrico, Ouk, Samedy, Tsai, Jennifer J., Smith, Odette M., Levy, Emily R., Kreines, Fabiana M., Ziegler, Carly G.K., Scallion, Mary I., Doubrovin, Mikhail, Heller, Glenn, Younes, Anas, O’Reilly, Richard J., van den Brink, Marcel R.M., Zakrzewski, Johannes L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715937/
https://ncbi.nlm.nih.gov/pubmed/26744524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2814
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