Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses

NF-κB plays a variety of roles in oncogenesis and immunity that may be beneficial for therapeutic targeting, but strategies to selectively inhibit NF-κB to exert antitumor activity have been elusive. Here we describe IT-901, a bioactive naphthalenethiobarbiturate derivative that potently inhibits th...

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Vydáno v:Cancer Res
Hlavní autoři: Shono, Yusuke, Tuckett, Andrea Z., Liou, Hsiou-Chi, Doubrovina, Ekaterina, Derenzini, Enrico, Ouk, Samedy, Tsai, Jennifer J., Smith, Odette M., Levy, Emily R., Kreines, Fabiana M., Ziegler, Carly G.K., Scallion, Mary I., Doubrovin, Mikhail, Heller, Glenn, Younes, Anas, O’Reilly, Richard J., van den Brink, Marcel R.M., Zakrzewski, Johannes L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715937/
https://ncbi.nlm.nih.gov/pubmed/26744524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2814
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