Donor CD19-CAR T Cells Exert Potent Graft-versus-Lymphoma Activity With Diminished Graft-versus-Host Activity

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments. Chimeric antigen receptors (CARs) direct tumor cell recognition of adoptive...

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Publicado no:Nat Med
Main Authors: Ghosh, Arnab, Smith, Melody, James, Scott E., Davila, Marco L., Velardi, Enrico, Argyropoulos, Kimon V., Gunset, Gertrude, Perna, Fabiana, Kreines, Fabiana M., Levy, Emily R., Lieberman, Sophie, Jay, Hilary, Tuckett, Andrea Z., Zakrzewski, Johannes L., Tan, Lisa, Young, Lauren F., Takvorian, Kate, Dudakov, Jarrod A., Jenq, Robert R., Hanash, Alan M., Motta, Ana Carolina F., Murphy, George F., Liu, Chen, Schietinger, Andrea, Sadelain, Michel, van den Brink, Marcel R.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528161/
https://ncbi.nlm.nih.gov/pubmed/28067900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4258
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