Donor CD19-CAR T Cells Exert Potent Graft-versus-Lymphoma Activity With Diminished Graft-versus-Host Activity

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments. Chimeric antigen receptors (CARs) direct tumor cell recognition of adoptive...

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Bibliografiska uppgifter
I publikationen:Nat Med
Huvudupphovsmän: Ghosh, Arnab, Smith, Melody, James, Scott E., Davila, Marco L., Velardi, Enrico, Argyropoulos, Kimon V., Gunset, Gertrude, Perna, Fabiana, Kreines, Fabiana M., Levy, Emily R., Lieberman, Sophie, Jay, Hilary, Tuckett, Andrea Z., Zakrzewski, Johannes L., Tan, Lisa, Young, Lauren F., Takvorian, Kate, Dudakov, Jarrod A., Jenq, Robert R., Hanash, Alan M., Motta, Ana Carolina F., Murphy, George F., Liu, Chen, Schietinger, Andrea, Sadelain, Michel, van den Brink, Marcel R.M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528161/
https://ncbi.nlm.nih.gov/pubmed/28067900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4258
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