ACUTE ELEVATIONS OF BRAIN KYNURENIC ACID IMPAIR COGNITIVE FLEXIBILITY: NORMALIZATION BY THE ALPHA 7 POSITIVE MODULATOR GALANTAMINE

Por Alexander, Kathleen S., Wu, Hui-Qiu, Schwarcz, Robert, Bruno, John P.
Publicado em 2011

KYNURENINES IN THE MAMMALIAN BRAIN: WHEN PHYSIOLOGY MEETS PATHOLOGY

Por Schwarcz, Robert, Bruno, John P., Muchowski, Paul J., Wu, Hui-Qiu
Publicado em 2012

GC/MS/MS DETECTION OF EXTRACELLULAR KYNURENINE AND RELATED METABOLITES IN NORMAL AND LESIONED RAT BRAIN

Por Notarangelo, Francesca M., Wu, Hui-Qiu, Macherone, Anthony, Graham, David R., Schwarcz, Robert
Publicado em 2011

PRE- AND POSTNATAL EXPOSURE TO KYNURENINE CAUSES COGNITIVE DEFICITS IN ADULTHOOD

Por Pocivavsek, Ana, Wu, Hui-Qiu, Elmer, Greg I., Bruno, John P., Schwarcz, Robert
Publicado em 2012

DOPAMINE RECEPTOR ACTIVATION REVEALS A NOVEL, KYNURENATE-SENSITIVE COMPONENT OF STRIATAL NMDA NEUROTOXICITY

Por Poeggeler, Burkhard, Rassoulpour, Arash, Wu, Hui-Qiu, Guidetti, Paolo, Roberts, Rosalinda C., Schwarcz, Robert
Publicado em 2007

Targeting Kynurenine Aminotransferase II in Psychiatric Diseases: Promising Effects of an Orally Active Enzyme Inhibitor

Por Wu, Hui-Qiu, Okuyama, Masahiro, Kajii, Yasushi, Pocivavsek, Ana, Bruno, John P., Schwarcz, Robert
Publicado em 2014

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

Por Pocivavsek, Ana, Wu, Hui-Qiu, Potter, Michelle C, Elmer, Greg I, Pellicciari, Roberto, Schwarcz, Robert
Publicado em 2011

Early Developmental Elevations of Brain Kynurenic Acid Impair Cognitive Flexibility in Adults: Reversal with Galantamine

Por Alexander, Kathleen S., Pocivavsek, Ana, Wu, Hui-Qiu, Pershing, Michelle L., Schwarcz, Robert, Bruno, John P.
Publicado em 2013

The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex

Por Wu, Hui-Qiu, Pereira, Edna F. R., Bruno, John P., Pellicciari, Roberto, Albuquerque, Edson X., Schwarcz, Robert
Publicado em 2009

Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

Por Potter, Michelle C, Elmer, Greg I, Bergeron, Richard, Albuquerque, Edson X, Guidetti, Paolo, Wu, Hui-Qiu, Schwarcz, Robert
Publicado em 2010

Enzymatic transamination of d-kynurenine generates kynurenic acid in rat and human brain

Por Pérez-de la Cruz, Veronica, Amori, Laura, Sathyasaikumar, Korrapati V., Wang, Xiao-Dan, Notarangelo, Francesca M., Wu, Hui-Qiu, Schwarcz, Robert
Publicado em 2012

Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN

Por Giorgini, Flaviano, Huang, Shao-Yi, Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Thomas, Marian A. R., Tararina, Margarita, Wu, Hui-Qiu, Schwarcz, Robert, Muchowski, Paul J.
Publicado em 2013

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/Glycine(B)-Site Inhibition

Por Zanos, Panos, Piantadosi, Sean C., Wu, Hui-Qiu, Pribut, Heather J., Dell, Matthew J., Can, Adem, Snodgrass, H. Ralph, Zarate, Carlos A., Schwarcz, Robert, Gould, Todd D.
Publicado no J Pharmacol Exp Ther (2015)

Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

Por Justinova, Zuzana, Mascia, Paola, Wu, Hui-Qiu, Secci, Maria E., Redhi, Godfrey H., Panlilio, Leigh V., Scherma, Maria, Barnes, Chanel, Parashos, Alexandra, Zara, Tamara, Fratta, Walter, Solinas, Marcello, Pistis, Marco, Bergman, Jack, Kangas, Brian D., Ferré, Sergi, Tanda, Gianluigi, Schwarcz, Robert, Goldberg, Steven R.
Publicado em 2013

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

Por Zwilling, Daniel, Huang, Shao-Yi, Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Guidetti, Paolo, Wu, Hui-Qiu, Lee, Jason, Truong, Jennifer, Andrews-Zwilling, Yaisa, Hsieh, Eric W., Louie, Jamie Y., Wu, Tiffany, Scearce-Levie, Kimberly, Patrick, Christina, Adame, Anthony, Giorgini, Flaviano, Moussaoui, Saliha, Laue, Grit, Rassoulpour, Arash, Flik, Gunnar, Huang, Yadong, Muchowski, Joseph M., Masliah, Eliezer, Schwarcz, Robert, Muchowski, Paul J.
Publicado em 2011