Early Developmental Elevations of Brain Kynurenic Acid Impair Cognitive Flexibility in Adults: Reversal with Galantamine

Levels of kynurenic acid (KYNA), an endogenous α7 nicotinic acetylcholine receptor (α7nAChR) antagonist, are elevated in the brain of patients with schizophrenia (SZ) and might contribute to the pathophysiology and cognitive deficits seen in the disorder. As developmental vulnerabilities contribute...

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Bibliografiske detaljer
Main Authors: Alexander, Kathleen S., Pocivavsek, Ana, Wu, Hui-Qiu, Pershing, Michelle L., Schwarcz, Robert, Bruno, John P.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622758/
https://ncbi.nlm.nih.gov/pubmed/23395862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.01.063
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