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Early Developmental Elevations of Brain Kynurenic Acid Impair Cognitive Flexibility in Adults: Reversal with Galantamine
Levels of kynurenic acid (KYNA), an endogenous α7 nicotinic acetylcholine receptor (α7nAChR) antagonist, are elevated in the brain of patients with schizophrenia (SZ) and might contribute to the pathophysiology and cognitive deficits seen in the disorder. As developmental vulnerabilities contribute...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3622758/ https://ncbi.nlm.nih.gov/pubmed/23395862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.01.063 |
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