Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

Kynurenic acid (KYNA), an astrocyte-derived metabolite, antagonizes the α7 nicotinic acetylcholine receptor (α7nAChR) and, possibly, the glycine co-agonist site of the NMDA receptor at endogenous brain concentrations. As both receptors are involved in cognitive processes, KYNA elevations may aggrava...

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Detalhes bibliográficos
Main Authors: Pocivavsek, Ana, Wu, Hui-Qiu, Potter, Michelle C, Elmer, Greg I, Pellicciari, Roberto, Schwarcz, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176574/
https://ncbi.nlm.nih.gov/pubmed/21796108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.127
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