Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

At endogenous brain concentrations, the astrocyte-derived metabolite kynurenic acid (KYNA) antagonizes the α7 nicotinic acetylcholine receptor and, possibly, the glycine co-agonist site of the NMDA receptor. The functions of these two receptors, which are intimately involved in synaptic plasticity a...

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Bibliographic Details
Main Authors: Potter, Michelle C, Elmer, Greg I, Bergeron, Richard, Albuquerque, Edson X, Guidetti, Paolo, Wu, Hui-Qiu, Schwarcz, Robert
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055476/
https://ncbi.nlm.nih.gov/pubmed/20336058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.39
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