ELEVATED LEVELS OF KYNURENIC ACID DURING GESTATION PRODUCE NEUROCHEMICAL, MORPHOLOGICAL, AND COGNITIVE DEFICITS IN ADULTHOOD: IMPLICATIONS FOR SCHIZOPHRENIA

The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha 7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ). We reported that increases of brain KYNA in rats, through dietary exposure to its precursor kynurenine from e...

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Vydáno v:Neuropharmacology
Hlavní autoři: Pershing, Michelle L., Bortz, David M., Pocivavsek, Ana, Fredericks, Peter J., Jørgensen, Christinna V., Vunck, Sarah A., Leuner, Benedetta, Schwarcz, Robert, Bruno, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731221/
https://ncbi.nlm.nih.gov/pubmed/25446576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.10.017
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