ELEVATED LEVELS OF KYNURENIC ACID DURING GESTATION PRODUCE NEUROCHEMICAL, MORPHOLOGICAL, AND COGNITIVE DEFICITS IN ADULTHOOD: IMPLICATIONS FOR SCHIZOPHRENIA

The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha 7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ). We reported that increases of brain KYNA in rats, through dietary exposure to its precursor kynurenine from e...

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Bibliografiske detaljer
Udgivet i:Neuropharmacology
Main Authors: Pershing, Michelle L., Bortz, David M., Pocivavsek, Ana, Fredericks, Peter J., Jørgensen, Christinna V., Vunck, Sarah A., Leuner, Benedetta, Schwarcz, Robert, Bruno, John P.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731221/
https://ncbi.nlm.nih.gov/pubmed/25446576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.10.017
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