Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN

Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway (KP) of tryptophan degradation, has been suggested to play a major role in physiological and pathological events involving bioactive KP metabolites. To explore this role in greater detail, we generated mice with a targeted...

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Bibliographische Detailangaben
Hauptverfasser: Giorgini, Flaviano, Huang, Shao-Yi, Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Thomas, Marian A. R., Tararina, Margarita, Wu, Hui-Qiu, Schwarcz, Robert, Muchowski, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868768/
https://ncbi.nlm.nih.gov/pubmed/24189070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503813
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