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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington's disease
Huntington's disease (HD) is a fatal neurodegenerative disorder that is caused by an expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt)(1), which leads to its aggregation in nuclear and cytoplasmic inclusion bodies(2). We recently reported the identification of 52 loss-o...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449881/ https://ncbi.nlm.nih.gov/pubmed/15806102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1542 |
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