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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington's disease

Huntington's disease (HD) is a fatal neurodegenerative disorder that is caused by an expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt)(1), which leads to its aggregation in nuclear and cytoplasmic inclusion bodies(2). We recently reported the identification of 52 loss-o...

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Détails bibliographiques
Auteurs principaux: Giorgini, Flaviano, Guidetti, Paolo, Nguyen, QuangVu, Bennett, Simone C., Muchowski, Paul J.
Format: Artigo
Langue:Inglês
Publié: 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449881/
https://ncbi.nlm.nih.gov/pubmed/15806102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1542
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