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Structural basis of kynurenine 3-monooxygenase inhibition
Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (i.e. kynurenine pathway), leads to amelioration of Huntington’s disease-relevant phenotypes in yeast, fruit fly, and mouse models(1–5), as well as a mouse model of Alzheimer’s disease(3). KMO is...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3736096/ https://ncbi.nlm.nih.gov/pubmed/23575632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12039 |
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