A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Dysregulation of the kynurenine pathway (KP) leads to imbalances in neuroactive metabolites associated with the pathogenesis of several neurodegenerative disorders, including Huntington’s disease (HD). Inhibition of the enzyme kynurenine 3-monooxygenase (KMO) in the KP normalises these metabolic imb...

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Publicado no:Commun Biol
Main Authors: Zhang, Shaowei, Sakuma, Michiyo, Deora, Girdhar S., Levy, Colin W., Klausing, Alex, Breda, Carlo, Read, Kevin D., Edlin, Chris D., Ross, Benjamin P., Wright Muelas, Marina, Day, Philip J., O’Hagan, Stephen, Kell, Douglas B., Schwarcz, Robert, Leys, David, Heyes, Derren J., Giorgini, Flaviano, Scrutton, Nigel S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656724/
https://ncbi.nlm.nih.gov/pubmed/31372510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0520-5
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