A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Dysregulation of the kynurenine pathway (KP) leads to imbalances in neuroactive metabolites associated with the pathogenesis of several neurodegenerative disorders, including Huntington’s disease (HD). Inhibition of the enzyme kynurenine 3-monooxygenase (KMO) in the KP normalises these metabolic imb...

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Bibliografske podrobnosti
izdano v:Commun Biol
Main Authors: Zhang, Shaowei, Sakuma, Michiyo, Deora, Girdhar S., Levy, Colin W., Klausing, Alex, Breda, Carlo, Read, Kevin D., Edlin, Chris D., Ross, Benjamin P., Wright Muelas, Marina, Day, Philip J., O’Hagan, Stephen, Kell, Douglas B., Schwarcz, Robert, Leys, David, Heyes, Derren J., Giorgini, Flaviano, Scrutton, Nigel S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656724/
https://ncbi.nlm.nih.gov/pubmed/31372510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0520-5
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