A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Dysregulation of the kynurenine pathway (KP) leads to imbalances in neuroactive metabolites associated with the pathogenesis of several neurodegenerative disorders, including Huntington’s disease (HD). Inhibition of the enzyme kynurenine 3-monooxygenase (KMO) in the KP normalises these metabolic imb...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Commun Biol
Päätekijät: Zhang, Shaowei, Sakuma, Michiyo, Deora, Girdhar S., Levy, Colin W., Klausing, Alex, Breda, Carlo, Read, Kevin D., Edlin, Chris D., Ross, Benjamin P., Wright Muelas, Marina, Day, Philip J., O’Hagan, Stephen, Kell, Douglas B., Schwarcz, Robert, Leys, David, Heyes, Derren J., Giorgini, Flaviano, Scrutton, Nigel S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656724/
https://ncbi.nlm.nih.gov/pubmed/31372510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0520-5
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