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The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington’s Disease
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been implicated in the pathophysiology of neurodegenerative disorders, including Huntington’s disease (HD) [1]. A central hallmark of HD is neurodegeneration caused by a polyglutamine expansion in the huntingtin (h...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929356/ https://ncbi.nlm.nih.gov/pubmed/21636279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.04.028 |
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