Glutathione peroxidase activity is neuroprotective in models of Huntington’s disease

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion encoding a polyglutamine tract in the huntingtin (htt) protein(1). Here, we report a genome-wide overexpression suppressor screen which identified 317 open reading frames that ameliorate toxicity of a mu...

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Main Authors: Mason, Robert P., Casu, Massimiliano, Butler, Nicola, Breda, Carlo, Campesan, Susanna, Clapp, Jannine, Green, Edward W., Dhulkhed, Devyani, Kyriacou, Charalambos P., Giorgini, Flaviano
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040417/
https://ncbi.nlm.nih.gov/pubmed/23974869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2732
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