Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease

Synapse abnormalities in Huntington's disease (HD) patients can precede clinical diagnosis and neuron loss by decades. The polyglutamine expansion in the huntingtin (htt) protein that underlies this disorder leads to perturbations in many cellular pathways, including the disruption of Rab11-dep...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Steinert, Joern R., Campesan, Susanna, Richards, Paul, Kyriacou, Charalambos P., Forsythe, Ian D., Giorgini, Flaviano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373239/
https://ncbi.nlm.nih.gov/pubmed/22466800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds117
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi