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Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease

Synapse abnormalities in Huntington's disease (HD) patients can precede clinical diagnosis and neuron loss by decades. The polyglutamine expansion in the huntingtin (htt) protein that underlies this disorder leads to perturbations in many cellular pathways, including the disruption of Rab11-dep...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Steinert, Joern R., Campesan, Susanna, Richards, Paul, Kyriacou, Charalambos P., Forsythe, Ian D., Giorgini, Flaviano
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373239/
https://ncbi.nlm.nih.gov/pubmed/22466800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds117
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