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Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease
Synapse abnormalities in Huntington's disease (HD) patients can precede clinical diagnosis and neuron loss by decades. The polyglutamine expansion in the huntingtin (htt) protein that underlies this disorder leads to perturbations in many cellular pathways, including the disruption of Rab11-dep...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373239/ https://ncbi.nlm.nih.gov/pubmed/22466800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds117 |
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