Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease

Synapse abnormalities in Huntington's disease (HD) patients can precede clinical diagnosis and neuron loss by decades. The polyglutamine expansion in the huntingtin (htt) protein that underlies this disorder leads to perturbations in many cellular pathways, including the disruption of Rab11-dep...

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Библиографические подробности
Главные авторы: Steinert, Joern R., Campesan, Susanna, Richards, Paul, Kyriacou, Charalambos P., Forsythe, Ian D., Giorgini, Flaviano
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373239/
https://ncbi.nlm.nih.gov/pubmed/22466800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds117
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