The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington’s Disease

Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been implicated in the pathophysiology of neurodegenerative disorders, including Huntington’s disease (HD) [1]. A central hallmark of HD is neurodegeneration caused by a polyglutamine expansion in the huntingtin (h...

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Detalhes bibliográficos
Main Authors: Campesan, Susanna, Green, Edward W., Breda, Carlo, Sathyasaikumar, Korrapati V., Muchowski, Paul J., Schwarcz, Robert, Kyriacou, Charalambos P., Giorgini, Flaviano
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929356/
https://ncbi.nlm.nih.gov/pubmed/21636279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.04.028
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