Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has highlighted the therapeutic potential of inhibiting two critical regulatory enzymes in this pathway—kynurenine-3-monooxygena...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Breda, Carlo, Sathyasaikumar, Korrapati V., Sograte Idrissi, Shama, Notarangelo, Francesca M., Estranero, Jasper G., Moore, Gareth G. L., Green, Edward W., Kyriacou, Charalambos P., Schwarcz, Robert, Giorgini, Flaviano
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868470/
https://ncbi.nlm.nih.gov/pubmed/27114543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604453113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados