Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has highlighted the therapeutic potential of inhibiting two critical regulatory enzymes in this pathway—kynurenine-3-monooxygena...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Breda, Carlo, Sathyasaikumar, Korrapati V., Sograte Idrissi, Shama, Notarangelo, Francesca M., Estranero, Jasper G., Moore, Gareth G. L., Green, Edward W., Kyriacou, Charalambos P., Schwarcz, Robert, Giorgini, Flaviano
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868470/
https://ncbi.nlm.nih.gov/pubmed/27114543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604453113
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