Tryptophan 2,3-Dioxygenfase and Indoleamine 2,3-Dioxygenase 1 Make Separate, Tissue-Specific Contributions to Basal and Inflammation-Induced Kynurenine Pathway Metabolism in Mice

In mammals, the majority of the essential amino acid tryptophan is degraded via the kynurenine pathway (KP). Several KP metabolites play distinct physiological roles, often linked to immune system functions, and may also be causally involved in human diseases including neurodegenerative disorders, s...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Larkin, Paul B., Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Funakoshi, Hiroshi, Nakamura, Toshikazu, Schwarcz, Robert, Muchowski, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808460/
https://ncbi.nlm.nih.gov/pubmed/27392942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.07.002
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