Tryptophan 2,3-Dioxygenfase and Indoleamine 2,3-Dioxygenase 1 Make Separate, Tissue-Specific Contributions to Basal and Inflammation-Induced Kynurenine Pathway Metabolism in Mice

In mammals, the majority of the essential amino acid tryptophan is degraded via the kynurenine pathway (KP). Several KP metabolites play distinct physiological roles, often linked to immune system functions, and may also be causally involved in human diseases including neurodegenerative disorders, s...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Larkin, Paul B., Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Funakoshi, Hiroshi, Nakamura, Toshikazu, Schwarcz, Robert, Muchowski, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808460/
https://ncbi.nlm.nih.gov/pubmed/27392942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.07.002
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