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Enzymatic transamination of d-kynurenine generates kynurenic acid in rat and human brain

In the mammalian brain, the α7 nicotinic and NMDA receptor antagonist kynurenic acid is synthesized by irreversible enzymatic transamination of the tryptophan metabolite l-kynure-nine. d-kynurenine, too, serves as a bioprecursor of kynurenic acid in several organs including the brain, but the conver...

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Detalhes bibliográficos
Main Authors: Pérez-de la Cruz, Veronica, Amori, Laura, Sathyasaikumar, Korrapati V., Wang, Xiao-Dan, Notarangelo, Francesca M., Wu, Hui-Qiu, Schwarcz, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929305/
https://ncbi.nlm.nih.gov/pubmed/22224417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07653.x
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