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Enzymatic transamination of d-kynurenine generates kynurenic acid in rat and human brain
In the mammalian brain, the α7 nicotinic and NMDA receptor antagonist kynurenic acid is synthesized by irreversible enzymatic transamination of the tryptophan metabolite l-kynure-nine. d-kynurenine, too, serves as a bioprecursor of kynurenic acid in several organs including the brain, but the conver...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929305/ https://ncbi.nlm.nih.gov/pubmed/22224417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07653.x |
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