Adaptive and Behavioral Changes in Kynurenine 3-monooxygenase Knockout Mice: Relevance to Psychotic Disorders

BACKGROUND: Kynurenine 3-monooxygenase (KMO) converts kynurenine to 3-hydroxykynurenine, and its inhibition shunts the kynurenine pathway - which is implicated as dysfunctional in various psychiatric disorders - towards enhanced synthesis of kynurenic acid (KYNA), an antagonist of both α7 nicotinic...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: Erhardt, Sophie, Pocivavsek, Ana, Repici, Mariaelena, Liu, Xi-Cong, Imbeault, Sophie, Maddison, Daniel C, Thomas, Marian AR, Smalley, Joshua L, Larsson, Markus K, Muchowski, Paul J, Giorgini, Flaviano, Schwarcz, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812460/
https://ncbi.nlm.nih.gov/pubmed/28187857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.12.011
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