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Targeting Kynurenine Aminotransferase II in Psychiatric Diseases: Promising Effects of an Orally Active Enzyme Inhibitor

Increased brain levels of the tryptophan metabolite kynurenic acid (KYNA) have been linked to cognitive dysfunctions in schizophrenia and other psychiatric diseases. In the rat, local inhibition of kynurenine aminotransferase II (KAT II), the enzyme responsible for the neosynthesis of readily mobili...

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Detalhes bibliográficos
Main Authors: Wu, Hui-Qiu, Okuyama, Masahiro, Kajii, Yasushi, Pocivavsek, Ana, Bruno, John P., Schwarcz, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934402/
https://ncbi.nlm.nih.gov/pubmed/24562494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbt157
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