Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement()

Fluctuations in the brain levels of the neuromodulator kynurenic acid may control cognitive processes and play a causative role in several catastrophic brain diseases. Elimination of the pyridoxal 5′-phosphate dependent enzyme kynurenine aminotransferase II reduces cerebral kynurenic acid synthesis...

Full description

Saved in:
Bibliographic Details
Main Authors: Rossi, Franca, Valentina, Casazza, Garavaglia, Silvia, Sathyasaikumar, Korrapati V., Schwarcz, Robert, Kojima, Shin-ichi, Okuwaki, Keisuke, Ono, Shin-ichiro, Kajii, Yasushi, Rizzi, Menico
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929320/
https://ncbi.nlm.nih.gov/pubmed/20684605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100464k
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items