Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement()

Fluctuations in the brain levels of the neuromodulator kynurenic acid may control cognitive processes and play a causative role in several catastrophic brain diseases. Elimination of the pyridoxal 5′-phosphate dependent enzyme kynurenine aminotransferase II reduces cerebral kynurenic acid synthesis...

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Autors principals: Rossi, Franca, Valentina, Casazza, Garavaglia, Silvia, Sathyasaikumar, Korrapati V., Schwarcz, Robert, Kojima, Shin-ichi, Okuwaki, Keisuke, Ono, Shin-ichiro, Kajii, Yasushi, Rizzi, Menico
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929320/
https://ncbi.nlm.nih.gov/pubmed/20684605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100464k
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