Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes

CONTEXT: Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan degradation, is an antagonist at N-methyl-d-aspartate and α7 nicotinic acetylcholine receptors and modulates glutamate, dopamine, and acetylcholine signaling. Cortical kynurenic acid concentrations are elevated in the brai...

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Главные авторы: Wonodi, Ikwunga, Stine, O. Colin, Sathyasaikumar, Korrapati V., Roberts, Rosalinda C., Mitchell, Braxton D., Hong, L. Elliot, Kajii, Yasushi, Thaker, Gunvant K., Schwarcz, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855543/
https://ncbi.nlm.nih.gov/pubmed/21727251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archgenpsychiatry.2011.71
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