GC/MS/MS DETECTION OF EXTRACELLULAR KYNURENINE AND RELATED METABOLITES IN NORMAL AND LESIONED RAT BRAIN

We describe here a GC/MS/MS method for the sensitive and concurrent determination of extracellular tryptophan and the kynurenine pathway metabolites kynurenine, 3-hydroxykynurenine (3-HK) and quinolinic acid (QUIN) in rat brain. This metabolic cascade is increasingly linked to the pathophysiology of...

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Bibliographic Details
Main Authors: Notarangelo, Francesca M., Wu, Hui-Qiu, Macherone, Anthony, Graham, David R., Schwarcz, Robert
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274646/
https://ncbi.nlm.nih.gov/pubmed/22239963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.12.032
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