Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery

Autor Kaserman, Joseph E., Wilson, Andrew A.
Vydáno v Chronic Obstr Pulm Dis (2018)

Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage

Autor Kaserman, Joseph E., Wilson, Andrew A.
Vydáno v Methods Mol Biol (2017)

The Prolonged Life-Span of Alveolar Macrophages

Autor Murphy, Jaime, Summer, Ross, Wilson, Andrew A., Kotton, Darrell N., Fine, Alan
Vydáno 2008

Multilineage transduction of resident lung cells in vivo by AAV2/8 for α(1)-antitrypsin gene therapy

Autor Payne, Julia G, Takahashi, Ayuko, Higgins, Michelle I, Porter, Emily L, Suki, Bela, Balazs, Alejandro, Wilson, Andrew A
Vydáno v Mol Ther Methods Clin Dev (2016)

Activation of the c‐Jun N‐terminal kinase pathway aggravates proteotoxicity of hepatic mutant Z alpha1‐antitrypsin

Autor Pastore, Nunzia, Attanasio, Sergio, Granese, Barbara, Castello, Raffaele, Teckman, Jeffrey, Wilson, Andrew A., Ballabio, Andrea, Brunetti‐Pierri, Nicola
Vydáno v Hepatology (2017)

Sustained Expression of α(1)-Antitrypsin after Transplantation of Manipulated Hematopoietic Stem Cells

Autor Wilson, Andrew A., Kwok, Letty W., Hovav, Avi-Hai, Ohle, Sarah J., Little, Frederic F., Fine, Alan, Kotton, Darrell N.
Vydáno 2008

Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo

Autor Repasy, Teresa, Lee, Jinhee, Marino, Simeone, Martinez, Nuria, Kirschner, Denise E., Hendricks, Gregory, Baker, Stephen, Wilson, Andrew A., Kotton, Darrell N., Kornfeld, Hardy
Vydáno 2013

Roles of Lung Epithelium in Neutrophil Recruitment during Pneumococcal Pneumonia

Autor Yamamoto, Kazuko, Ahyi, Ayele-Nati N., Pepper-Cunningham, Zachary A., Ferrari, Joseph D., Wilson, Andrew A., Jones, Matthew R., Quinton, Lee J., Mizgerd, Joseph P.
Vydáno 2014

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages

Autor Wilson, Andrew A., Murphy, George J., Hamakawa, Hiroshi, Kwok, Letty W., Srinivasan, Sreedevi, Hovav, Avi-Hai, Mulligan, Richard C., Amar, Salomon, Suki, Bela, Kotton, Darrell N.
Vydáno 2009

Ataluren, a New Therapeutic for Alpha-1 Antitrypsin–Deficient Individuals with Nonsense Mutations

Autor Reeves, Emer P., O’Dwyer, Ciara A., Dunlea, Danielle M., Wormald, Mark R., Hawkins, Padraig, Alfares, Mohammad, Kotton, Darrell N., Rowe, Steven M., Wilson, Andrew A., McElvaney, Noel G.
Vydáno v Am J Respir Crit Care Med (2018)

Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity

Autor Coleman, Fadie T, Blahna, Matthew T, Kamata, Hirofumi, Yamamoto, Kazuko, Zabinski, Mary C, Kramnik, Igor, Wilson, Andrew A, Kotton, Darrell N, Quinton, Lee J, Jones, Matthew R, Pelton, Stephen I, Mizgerd, Joseph P
Vydáno v J Infect Dis (2017)

Aberrant epithelial polarity cues drive the development of precancerous airway lesions

Autor Tilston-Lunel, Andrew, Mazzilli, Sarah, Kingston, Nathan M., Szymaniak, Aleksander D., Hicks-Berthet, Julia, Kern, Joseph G., Abo, Kristine, Reid, Mary E., Perdomo, Catalina, Wilson, Andrew A., Spira, Avrum, Beane, Jennifer, Varelas, Xaralabos
Vydáno v Proc Natl Acad Sci U S A (2021)

Lentiviral Delivery of RNAi for In Vivo Lineage-Specific Modulation of Gene Expression in Mouse Lung Macrophages

Autor Wilson, Andrew A, Kwok, Letty W, Porter, Emily L, Payne, Julie G, McElroy, Gregory S, Ohle, Sarah J, Greenhill, Sara R, Blahna, Matthew T, Yamamoto, Kazuko, Jean, Jyh C, Mizgerd, Joseph P, Kotton, Darrell N
Vydáno 2013

A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modeling and in vitro testing of novel therapeutics

Autor Giadone, Richard M., Rosarda, Jessica D., Akepati, Prithvi Reddy, Thomas, Arianne C., Boldbaatar, Batbold, James, Marianne F., Wilson, Andrew A., Sanchorawala, Vaishali, Connors, Lawreen H., Berk, John L., Wiseman, R. Luke, Murphy, George J.
Vydáno v Amyloid (2018)

Induced pluripotent stem cells model personalized variations in liver disease due to α(1)-antitrypsin deficiency

Autor Tafaleng, Edgar N., Chakraborty, Souvik, Han, Bing, Hale, Pamela, Wu, Wanquan, Soto-Gutierrez, Alejandro, Feghali-Bostwick, Carol A., Wilson, Andrew A., Kotton, Darrell N., Nagaya, Masaki, Strom, Stephen C., Chowdhury, Jayanta R., Stolz, Donna B., Perlmutter, David H., Fox, Ira J.
Vydáno v Hepatology (2015)

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells

Autor Kaserman, Joseph E., Hurley, Killian, Dodge, Mark, Villacorta-Martin, Carlos, Vedaie, Marall, Jean, Jyh-Chang, Liberti, Derek C., James, Marianne F., Higgins, Michelle I., Lee, Nora J., Washko, George R., San Jose Estepar, Raul, Teckman, Jeffrey, Kotton, Darrell N., Wilson, Andrew A.
Vydáno v Stem Cell Reports (2020)

Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

Autor Giadone, Richard M., Liberti, Derek C., Matte, Taylor M., Rosarda, Jessica D., Torres-Arancivia, Celia, Ghosh, Sabrina, Diedrich, Jolene K., Pankow, Sandra, Skvir, Nicholas, Jean, J.C., Yates, John R., Wilson, Andrew A., Connors, Lawreen H., Kotton, Darrell N., Wiseman, R. Luke, Murphy, George J.
Vydáno v Stem Cell Reports (2020)

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α(1)-antitrypsin deficiency

Autor Segeritz, Charis-Patricia, Rashid, Sheikh Tamir, de Brito, Miguel Cardoso, Serra, Maria Paola, Ordonez, Adriana, Morell, Carola Maria, Kaserman, Joseph E., Madrigal, Pedro, Hannan, Nicholas R.F., Gatto, Laurent, Tan, Lu, Wilson, Andrew A., Lilley, Kathryn, Marciniak, Stefan J., Gooptu, Bibek, Lomas, David A., Vallier, Ludovic
Vydáno v J Hepatol (2018)

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity

Autor Reeves, Emer P., Dunlea, Danielle M., McQuillan, Karen, O’Dwyer, Ciara A., Carroll, Tomás P., Saldova, Radka, Akepati, Prithvi Reddy, Wormald, Mark R., McElvaney, Oliver J., Shutchaidat, Vipatsorn, Henry, Michael, Meleady, Paula, Keenan, Joanne, Liberti, Derek C., Kotton, Darrell N., Rudd, Pauline M., Wilson, Andrew A., McElvaney, Noel G.
Vydáno v J Immunol (2019)

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Autor Huang, Jessie, Hume, Adam J., Abo, Kristine M., Werder, Rhiannon B., Villacorta-Martin, Carlos, Alysandratos, Konstantinos-Dionysios, Beermann, Mary Lou, Simone-Roach, Chantelle, Lindstrom-Vautrin, Jonathan, Olejnik, Judith, Suder, Ellen L., Bullitt, Esther, Hinds, Anne, Sharma, Arjun, Bosmann, Markus, Wang, Ruobing, Hawkins, Finn, Burks, Eric J., Saeed, Mohsan, Wilson, Andrew A., Mühlberger, Elke, Kotton, Darrell N.
Vydáno v bioRxiv (2020)