Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo

We previously reported that Mycobacterium tuberculosis triggers macrophage necrosis in vitro at a threshold intracellular load of ∼25 bacilli. This suggests a model for tuberculosis where bacilli invading lung macrophages at low multiplicity of infection proliferate to burst size and spread to naïve...

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Main Authors: Repasy, Teresa, Lee, Jinhee, Marino, Simeone, Martinez, Nuria, Kirschner, Denise E., Hendricks, Gregory, Baker, Stephen, Wilson, Andrew A., Kotton, Darrell N., Kornfeld, Hardy
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578792/
https://ncbi.nlm.nih.gov/pubmed/23436998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003190
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