Interleukin-6: obstacles to targeting a complex cytokine in critical illness

af McElvaney, Oliver J, Curley, Gerard F, Rose-John, Stefan, McElvaney, Noel G
Udgivet i Lancet Respir Med (2021)

Reply to Blot et al. and to Inoue et al.

af McElvaney, Oliver J., McEvoy, Natalie L., McElvaney, Noel G., Curley, Gerard F.
Udgivet i Am J Respir Crit Care Med (2021)

Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis

af McQuillan, Karen, Gargoum, Fatma, Murphy, Mark P., McElvaney, Oliver J., McElvaney, Noel G., Reeves, Emer P.
Udgivet i Front Pharmacol (2020)

Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function

af Reeves, Emer P, McCarthy, Cormac, McElvaney, Oliver J, Vijayan, Maya Sakthi N, White, Michelle M, Dunlea, Danielle M, Pohl, Kerstin, Lacey, Noreen, McElvaney, Noel G
Udgivet i World J Crit Care Med (2015)

Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency

af Franciosi, Alessandro N., Hobbs, Brian D., McElvaney, Oliver J., Molloy, Kevin, Hersh, Craig, Clarke, Louise, Gunaratnam, Cedric, Silverman, Edwin K., Carroll, Tomás P., McElvaney, Noel G.
Udgivet i Am J Respir Crit Care Med (2020)

Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung

af Vega-Carrascal, Isabel, Bergin, David A., McElvaney, Oliver J., McCarthy, Cormac, Banville, Nessa, Pohl, Kerstin, Hirashima, Mitsuomi, Kuchroo, Vijay K., Reeves, Emer P., McElvaney, Noel G.
Udgivet i J Immunol (2014)

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

af Bergin, David A., Reeves, Emer P., Meleady, Paula, Henry, Michael, McElvaney, Oliver J., Carroll, Tomás P., Condron, Claire, Chotirmall, Sanjay H., Clynes, Martin, O’Neill, Shane J., McElvaney, Noel G.
Udgivet 2010

Alpha-1 antitrypsin for cystic fibrosis complicated by severe cytokinemic COVID-19

af McElvaney, Oliver J, O'Connor, Eoin, McEvoy, Natalie L, Fraughan, Daniel D, Clarke, Jennifer, McElvaney, Oisín F, Gunaratnam, Cedric, O'Rourke, James, Curley, Gerard F, McElvaney, Noel G
Udgivet i J Cyst Fibros (2021)

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

af Hayes, Elaine, Murphy, Mark P., Pohl, Kerstin, Browne, Niall, McQuillan, Karen, Saw, Le Er, Foley, Clare, Gargoum, Fatma, McElvaney, Oliver J., Hawkins, Padraig, Gunaratnam, Cedric, McElvaney, Noel G., Reeves, Emer P.
Udgivet i Front Immunol (2020)

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

af Pohl, Kerstin, Hayes, Elaine, Keenan, Joanne, Henry, Michael, Meleady, Paula, Molloy, Kevin, Jundi, Bakr, Bergin, David A., McCarthy, Cormac, McElvaney, Oliver J., White, Michelle M., Clynes, Martin, Reeves, Emer P., McElvaney, Noel G.
Udgivet 2014

A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19

af McElvaney, Oliver J, Hobbs, Brian D, Qiao, Dandi, McElvaney, Oisín F, Moll, Matthew, McEvoy, Natalie L, Clarke, Jennifer, O'Connor, Eoin, Walsh, Seán, Cho, Michael H, Curley, Gerard F, McElvaney, Noel G
Udgivet i EBioMedicine (2020)

Corrigendum to ‘A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19’

af McElvaney, Oliver J, Hobbs, Brian D, Qiao, Dandi, McElvaney, Oisín F, Moll, Matthew, McEvoy, Natalie L, Clarke, Jennifer, O'Connor, Eoin, Walsh, Sean, Cho, Michael H, Curley, Gerard F, McElvaney, Noel G
Udgivet i EBioMedicine (2020)

Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency

af O'Brien, Michael E, Fee, Laura, Browne, Niall, Carroll, Tomás P, Meleady, Paula, Henry, Michael, McQuillan, Karen, Murphy, Mark P, Logan, Mark, McCarthy, Cormac, McElvaney, Oliver J, Reeves, Emer P, McElvaney, Noel G
Udgivet i Thorax (2020)

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease

af White, Michelle M., Geraghty, Patrick, Hayes, Elaine, Cox, Stephen, Leitch, William, Alfawaz, Bader, Lavelle, Gillian M., McElvaney, Oliver J., Flannery, Ryan, Keenan, Joanne, Meleady, Paula, Henry, Michael, Clynes, Martin, Gunaratnam, Cedric, McElvaney, Noel G., Reeves, Emer P.
Udgivet i EBioMedicine (2017)

Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fi...

af Reeves, Emer P., Banville, Nessa, Ryan, Dorothy M., O'Reilly, Niamh, Bergin, David A., Pohl, Kerstin, Molloy, Kevin, McElvaney, Oliver J., Alsaleh, Khalifah, Aljorfi, Ahmed, Kandalaft, Osama, O'Flynn, Eimear, Geraghty, Patrick, O'Neill, Shane J., McElvaney, Noel G.
Udgivet 2013

Prone positioning improves oxygenation and lung recruitment in patients with SARS-CoV-2 acute respiratory distress syndrome; a single centre cohort study of 20 consecutive patients

af Clarke, Jennifer, Geoghegan, Pierce, McEvoy, Natalie, Boylan, Maria, Ní Choileáin, Orna, Mulligan, Martin, Hogan, Grace, Keogh, Aoife, McElvaney, Oliver J., McElvaney, Oisín F., Bourke, John, McNicholas, Bairbre, Laffey, John G., McElvaney, Noel G., Curley, Gerard F.
Udgivet i BMC Res Notes (2021)

A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structu...

af McEvoy, Natalie L., Clarke, Jennifer L., Mc Elvaney, Oliver J., Mc Elvaney, Oisin F., Boland, Fiona, Hyland, Deirdre, Geoghegan, Pierce, Donnelly, Karen, Friel, Oisin, Cullen, Ailbhe, Collins, Ann M., Fraughen, Daniel, Martin-Loeches, Ignacio, Hennessy, Martina, Laffey, John G., Mc Elvaney, Noel G., Curley, Gerard F.
Udgivet i Trials (2021)

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity

af Reeves, Emer P., Dunlea, Danielle M., McQuillan, Karen, O’Dwyer, Ciara A., Carroll, Tomás P., Saldova, Radka, Akepati, Prithvi Reddy, Wormald, Mark R., McElvaney, Oliver J., Shutchaidat, Vipatsorn, Henry, Michael, Meleady, Paula, Keenan, Joanne, Liberti, Derek C., Kotton, Darrell N., Rudd, Pauline M., Wilson, Andrew A., McElvaney, Noel G.
Udgivet i J Immunol (2019)

Caspase-11 promotes allergic airway inflammation

af Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.
Udgivet i Nat Commun (2020)

Characterization of the Inflammatory Response to Severe COVID-19 Illness

af McElvaney, Oliver J., McEvoy, Natalie L., McElvaney, Oisín F., Carroll, Tomás P., Murphy, Mark P., Dunlea, Danielle M., Ní Choileáin, Orna, Clarke, Jennifer, O’Connor, Eoin, Hogan, Grace, Ryan, Daniel, Sulaiman, Imran, Gunaratnam, Cedric, Branagan, Peter, O’Brien, Michael E., Morgan, Ross K., Costello, Richard W., Hurley, Killian, Walsh, Seán, de Barra, Eoghan, McNally, Cora, McConkey, Samuel, Boland, Fiona, Galvin, Sinead, Kiernan, Fiona, O’Rourke, James, Dwyer, Rory, Power, Michael, Geoghegan, Pierce, Larkin, Caroline, O’Leary, Ruth Aoibheann, Freeman, James, Gaffney, Alan, Marsh, Brian, Curley, Gerard F., McElvaney, Noel G.
Udgivet i Am J Respir Crit Care Med (2020)