Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Secretory leukoprotease inhibitor (SLPI) is an anti-inflammatory protein present in respiratory secretions. Whilst epithelial cell SLPI is extensively studied, neutrophil associated SLPI is poorly characterised. Neutrophil function including chemotaxis and degranulation of proteolytic enzymes involv...

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Main Authors: Reeves, Emer P., Banville, Nessa, Ryan, Dorothy M., O'Reilly, Niamh, Bergin, David A., Pohl, Kerstin, Molloy, Kevin, McElvaney, Oliver J., Alsaleh, Khalifah, Aljorfi, Ahmed, Kandalaft, Osama, O'Flynn, Eimear, Geraghty, Patrick, O'Neill, Shane J., McElvaney, Noel G.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773400/
https://ncbi.nlm.nih.gov/pubmed/24073410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/560141
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