Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency

INTRODUCTION: Alpha-1 antitrypsin (AAT) deficiency (AATD) is associated with early onset emphysema. The aim of this study was to investigate whether AAT binding to plasma constituents could regulate their activation, and in AATD, exploit this binding event to better understand the condition and unco...

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Bibliografiske detaljer
Udgivet i:Thorax
Main Authors: O'Brien, Michael E, Fee, Laura, Browne, Niall, Carroll, Tomás P, Meleady, Paula, Henry, Michael, McQuillan, Karen, Murphy, Mark P, Logan, Mark, McCarthy, Cormac, McElvaney, Oliver J, Reeves, Emer P, McElvaney, Noel G
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Respiratory Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231451/
https://ncbi.nlm.nih.gov/pubmed/31959730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-214076
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