Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency

INTRODUCTION: Alpha-1 antitrypsin (AAT) deficiency (AATD) is associated with early onset emphysema. The aim of this study was to investigate whether AAT binding to plasma constituents could regulate their activation, and in AATD, exploit this binding event to better understand the condition and unco...

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Bibliografische gegevens
Gepubliceerd in:Thorax
Hoofdauteurs: O'Brien, Michael E, Fee, Laura, Browne, Niall, Carroll, Tomás P, Meleady, Paula, Henry, Michael, McQuillan, Karen, Murphy, Mark P, Logan, Mark, McCarthy, Cormac, McElvaney, Oliver J, Reeves, Emer P, McElvaney, Noel G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2020
Onderwerpen:
Respiratory Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231451/
https://ncbi.nlm.nih.gov/pubmed/31959730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-214076
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