Aberrant epithelial polarity cues drive the development of precancerous airway lesions

Molecular events that drive the development of precancerous lesions in the bronchial epithelium, which are precursors of lung squamous cell carcinoma (LUSC), are poorly understood. We demonstrate that disruption of epithelial cellular polarity, via the conditional deletion of the apical determinant...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tilston-Lunel, Andrew, Mazzilli, Sarah, Kingston, Nathan M., Szymaniak, Aleksander D., Hicks-Berthet, Julia, Kern, Joseph G., Abo, Kristine, Reid, Mary E., Perdomo, Catalina, Wilson, Andrew A., Spira, Avrum, Beane, Jennifer, Varelas, Xaralabos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106308/
https://ncbi.nlm.nih.gov/pubmed/33903236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019282118
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