Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road

Por Wang, Liang-Chuan S, Riese, Matthew J, Moon, Edmund K, Albelda, Steven M
Publicado em 2013

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

Por Richman, Sarah A., Wang, Liang-Chuan, Khire, Uday R., Albelda, Steven M., Milone, Michael C.
Publicado no Mol Ther (2020)

Activation of the Nucleotide Oligomerization Domain Signaling Pathway by the Non-bacterially Derived Xanthone Drug 5′6-Dimethylxanthenone-4-acetic Acid (Vadimezan)

Por Cheng, Guanjun, Sun, Jing, Fridlender, Zvi G., Wang, Liang-Chuan S., Ching, Lai-Ming, Albelda, Steven M.
Publicado em 2010

Activation of Mitogen-Activated Protein Kinases by 5, 6-Dimethylxanthenone-4-Acetic Acid (DMXAA) Plays an Important Role in Macrophage Stimulation

Por Sun, Jing, Wang, Liang-Chuan S., Fridlender, Zvi G., Kapoor, Veena, Cheng, Guanjun, Ching, Lai-Ming, Albelda, Steven M.
Publicado em 2011

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

Por Richman, Sarah A., Wang, Liang-Chuan, Moon, Edmund K., Khire, Uday R., Albelda, Steven M., Milone, Michael C.
Publicado no Mol Ther (2020)

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines

Por Moon, Edmund K., Wang, Liang-Chuan S., Bekdache, Kheng, Lynn, Rachel C., Lo, Albert, Thorne, Stephen H., Albelda, Steven M.
Publicado no Oncoimmunology (2018)

Monocyte Chemoattractant Protein–1 Blockade Inhibits Lung Cancer Tumor Growth by Altering Macrophage Phenotype and Activating CD8(+) Cells

Por Fridlender, Zvi G., Kapoor, Veena, Buchlis, George, Cheng, Guanjun, Sun, Jing, Wang, Liang-Chuan S., Singhal, Sunil, Snyder, Linda A., Albelda, Steven M.
Publicado em 2011

The receptor for advanced glycation end products mediates lung endothelial activation by RBCs

Por Mangalmurti, Nilam S., Friedman, Jessica L., Wang, Liang-Chuan, Stolz, Donna, Muthukumaran, Geetha, Siegel, Don L., Schmidt, Ann Marie, Lee, Janet S., Albelda, Steven M.
Publicado em 2013

Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

Por Riese, Matthew J., Wang, Liang-Chuan S., Moon, Edmund K., Joshi, Rohan P., Ranganathan, Anjana, June, Carl H., Koretzky, Gary A., Albelda, Steven M.
Publicado em 2013

Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors

Por Baek, Kwan-Hyuck, Bhang, Dongha, Zaslavsky, Alexander, Wang, Liang-Chuan, Vachani, Anil, Kim, Carla F., Albelda, Steven M., Evan, Gerard I., Ryeom, Sandra
Publicado em 2013

Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery

Por Predina, Jarrod, Eruslanov, Evgeniy, Judy, Brendan, Kapoor, Veena, Cheng, Guanjun, Wang, Liang-Chuan, Sun, Jing, Moon, Edmund K., Fridlender, Zvi Gregorio, Albelda, Steven, Singhal, Sunil
Publicado em 2013

Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404)

Por Wang, Liang-Chuan S, Thomsen, Lotte, Sutherland, Rachel, Reddy, Charu B, Tijono, Sofian M, Chen, Chun-Jen J, Angel, Catherine E, Dunbar, P Rod, Ching, Lai-Ming
Publicado em 2009

CCL2 Blockade Augments Cancer Immunotherapy

Por Fridlender, Zvi G., Buchlis, George, Kapoor, Veena, Cheng, Guanjun, Sun, Jing, Singhal, Sunil, Crisanti, Cecilia, Wang, Liang-Chuan S, Heitjan, Daniel, Snyder, Linda A., Albelda, Steven M.
Publicado em 2009

Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T Cells Expressing a Mesothelin - Specific Chimeric Antibody Receptor

Por Moon, Edmund K., Carpenito, Carmine, Sun, Jing, Wang, Liang-Chuan S, Kapoor, Veena, Predina, Jarrod, Powell, Daniel J., Riley, James L., June, Carl H., Albelda, Steven M.
Publicado em 2011

Mesothelin, a novel immunotherapy target for triple negative breast cancer

Por Tchou, Julia, Wang, Liang-Chuan, Selven, Ben, Zhang, Hongtao, Conejo-Garcia, Jose, Borghaei, Hossein, Vondeheide, Robert H, Albelda, Steven M., June, Carl H, Zhang, Paul J
Publicado no Breast Cancer Res Treat (2012)

Labeling of Oxidizable Proteins with a Photoactivatable Analog of the Antitumor Agent DMXAA: Evidence for Redox Signaling in Its Mode of Action

Por Brauer, Romy, Wang, Liang-Chuan S, Woon, See-Tarn, Bridewell, David JA, Henare, Kimiora, Malinger, Dieter, Palmer, Brian D, Vogel, Stefanie N, Kieda, Claudine, Tijono, Sofian M, Ching, Lai-Ming
Publicado em 2010

Treating Tumors With a Vaccinia Virus Expressing IFNβ Illustrates the Complex Relationships Between Oncolytic Ability and Immunogenicity

Por Wang, Liang-Chuan S, Lynn, Rachel C, Cheng, Guanjun, Alexander, Edward, Kapoor, Veena, Moon, Edmund K, Sun, Jing, Fridlender, Zvi G, Isaacs, Stuart N, Thorne, Stephen H, Albelda, Steven M
Publicado em 2012

CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis

Por Liu, Yuhong, O'Leary, Claire E., Wang, Liang-Chuan S., Bhatti, Tricia R., Dai, Ning, Kapoor, Veena, Liu, Peihui, Mei, Junjie, Guo, Lei, Oliver, Paula M., Albelda, Steven M., Worthen, G. Scott
Publicado no Oncoimmunology (2015)

HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells

Por Xiao, Haiyan, Jiao, Jing, Wang, Liqing, O’Brien, Shaun, Newick, Kheng, Wang, Liang-Chuan S., Falkensammer, Eva, Liu, Yujie, Han, Rongxiang, Kapoor, Veena, Hansen, Finn K., Kurz, Thomas, Hancock, Wayne W., Beier, Ulf H.
Publicado no Int J Cancer (2016)

Generation of Potent T-cell Immunotherapy for Cancer using DAP12-based, Multichain, Chimeric Immunoreceptors

Por Wang, Enxiu, Wang, Liang-Chuan, Tsai, Ching-Yi, Bhoj, Vijay, Gershenson, Zack, Moon, Edmund, Newick, Kheng, Sun, Jing, Lo, Albert, Baradet, Timothy, Feldman, Michael D., Barrett, David, Puré, Ellen, Albelda, Steven, Milone, Michael C.
Publicado no Cancer Immunol Res (2015)