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Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors
Progression of premalignant lesions is restrained by oncogene-induced senescence. Oncogenic Ras triggers senescence in many organs, including the lung, which exhibits high levels of the angiogenesis inhibitor thrombospondin-1 (TSP-1). The contribution of TSP-1 upregulation to the modulation of tumor...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3784530/ https://ncbi.nlm.nih.gov/pubmed/24018559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67465 |
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