Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors

Progression of premalignant lesions is restrained by oncogene-induced senescence. Oncogenic Ras triggers senescence in many organs, including the lung, which exhibits high levels of the angiogenesis inhibitor thrombospondin-1 (TSP-1). The contribution of TSP-1 upregulation to the modulation of tumor...

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Autori principali: Baek, Kwan-Hyuck, Bhang, Dongha, Zaslavsky, Alexander, Wang, Liang-Chuan, Vachani, Anil, Kim, Carla F., Albelda, Steven M., Evan, Gerard I., Ryeom, Sandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784530/
https://ncbi.nlm.nih.gov/pubmed/24018559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67465
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