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Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

Recent clinical trials have shown promise in the use of chimeric antigen receptor(CAR)-transduced T cells; however, augmentation of their activity may broaden their clinical utility and improve their efficacy. We hypothesized that, since CAR action requires proteins essential for TCR signal transduc...

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Bibliografski detalji
Glavni autori: Riese, Matthew J., Wang, Liang-Chuan S., Moon, Edmund K., Joshi, Rohan P., Ranganathan, Anjana, June, Carl H., Koretzky, Gary A., Albelda, Steven M.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686869/
https://ncbi.nlm.nih.gov/pubmed/23576561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3874
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