The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

Diacylglycerol (DAG) is a critical second messenger that mediates T cell receptor (TCR)–stimulated signaling. The abundance of DAG is reduced by the diacylglycerol kinases (DGKs), which catalyze the conversion of DAG to phosphatidic acid (PA) and thus inhibit DAG-mediated signaling. In T cells, the...

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Bibliographic Details
Main Authors:	Joshi, Rohan P., Schmidt, Amanda M., Das, Jayajit, Pytel, Dariusz, Riese, Matthew J., Lester, Melissa, Diehl, J. Alan, Behrens, Edward M., Kambayashi, Taku, Koretzky, Gary A.
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4096120/ https://ncbi.nlm.nih.gov/pubmed/24280043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004373
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The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

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