Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404)

5,6-Dimethylxanthenone-4-acetic acid (DMXAA) acts through tumor vascular disruption and cytokine production and is the first of its class to enter phase 3 trials. We characterized leukocytes and cytokines in murine Colon 38 tumors before and after DMXAA treatment. Tumor mass declined 50% 24 hours af...

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Detalhes bibliográficos
Main Authors: Wang, Liang-Chuan S, Thomsen, Lotte, Sutherland, Rachel, Reddy, Charu B, Tijono, Sofian M, Chen, Chun-Jen J, Angel, Catherine E, Dunbar, P Rod, Ching, Lai-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713591/
https://ncbi.nlm.nih.gov/pubmed/19649209
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