Labeling of Oxidizable Proteins with a Photoactivatable Analog of the Antitumor Agent DMXAA: Evidence for Redox Signaling in Its Mode of Action

The signaling pathway(s) and molecular target(s) for 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a tumor vascular disrupting agent in late stages of clinical development, are still undefined. As an approach toward identifying potential targets for DMXAA, a tritiated azido-analog of DMXAA was used...

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Autores principales: Brauer, Romy, Wang, Liang-Chuan S, Woon, See-Tarn, Bridewell, David JA, Henare, Kimiora, Malinger, Dieter, Palmer, Brian D, Vogel, Stefanie N, Kieda, Claudine, Tijono, Sofian M, Ching, Lai-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933696/
https://ncbi.nlm.nih.gov/pubmed/20824052
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