Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

BACKGROUND: Species selectivity of DMXAA (5,6-dimethylxanthenone-4-acetic acid, Vadimezan) for murine cells over human cells could explain in part the recent disappointing phase III trials clinical results when preclinical studies were so promising. To identify analogues with greater human clinical...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tijono, S M, Guo, K, Henare, K, Palmer, B D, Wang, L-C S, Albelda, S M, Ching, L-M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619269/
https://ncbi.nlm.nih.gov/pubmed/23481185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.101
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados