Generation of Potent T-cell Immunotherapy for Cancer using DAP12-based, Multichain, Chimeric Immunoreceptors

Chimeric antigen receptors (CAR) bearing an antigen-binding domain linked in cis to the cytoplasmic domains of CD3ζ and costimulatory receptors have provided a potent method for engineering T-cell cytotoxicity towards B-cell leukemia and lymphoma. However, resistance to immunotherapy due to loss of...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Wang, Enxiu, Wang, Liang-Chuan, Tsai, Ching-Yi, Bhoj, Vijay, Gershenson, Zack, Moon, Edmund, Newick, Kheng, Sun, Jing, Lo, Albert, Baradet, Timothy, Feldman, Michael D., Barrett, David, Puré, Ellen, Albelda, Steven, Milone, Michael C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490943/
https://ncbi.nlm.nih.gov/pubmed/25941351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0054
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