Augmentation of CAR T cell trafficking and antitumor efficacy by blocking protein kinase A (PKA) localization

Antitumor treatments based on the infusion of T cells expressing chimeric antigen receptors (CAR T cells) are still relatively ineffective for solid tumors, due to the presence of immunosuppressive mediators (such as prostaglandin E(2) (PGE(2)) and adenosine) and poor T-cell trafficking. PGE(2) and...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Newick, Kheng, O’Brien, Shaun, Sun, Jing, Kapoor, Veena, Maceyko, Steven, Lo, Albert, Pure, Ellen, Moon, Edmund, Albelda, Steven M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891259/
https://ncbi.nlm.nih.gov/pubmed/27045023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0263
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