Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

Chimeric antigen receptor (CAR)-modified T cells are endowed with novel antigen specificity and are most often administered to patients without an engineered mechanism to control the CAR T cells once infused. “Suicide switches” such as the small molecule-controlled, inducible caspase-9 (iCas9) syste...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Richman, Sarah A., Wang, Liang-Chuan, Khire, Uday R., Albelda, Steven M., Milone, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335755/
https://ncbi.nlm.nih.gov/pubmed/32559430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.004
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