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Translating in vitro ligand bias into in vivo efficacy
It is increasingly apparent that ligand structure influences both the efficiency with which G protein-coupled receptors (GPCRs) engage their downstream effectors and the manner in which they are activated. Thus, ‘biased’ agonists, synthetic ligands whose intrinsic efficacy differs from the native li...
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| Publicado en: | Cell Signal |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5675828/ https://ncbi.nlm.nih.gov/pubmed/28495495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.05.002 |
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