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Delineation of a Conserved Arrestin-Biased Signaling Repertoire In Vivo
Biased G protein–coupled receptor agonists engender a restricted repertoire of downstream events from their cognate receptors, permitting them to produce mixed agonist-antagonist effects in vivo. While this opens the possibility of novel therapeutics, it complicates rational drug design, since the i...
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| 出版年: | Mol Pharmacol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366796/ https://ncbi.nlm.nih.gov/pubmed/25637603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095224 |
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