Delineation of a Conserved Arrestin-Biased Signaling Repertoire In Vivo

Biased G protein–coupled receptor agonists engender a restricted repertoire of downstream events from their cognate receptors, permitting them to produce mixed agonist-antagonist effects in vivo. While this opens the possibility of novel therapeutics, it complicates rational drug design, since the i...

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Publicado no:Mol Pharmacol
Main Authors: Maudsley, Stuart, Martin, Bronwen, Gesty-Palmer, Diane, Cheung, Huey, Johnson, Calvin, Patel, Shamit, Becker, Kevin G., Wood, William H., Zhang, Yongqing, Lehrmann, Elin, Luttrell, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366796/
https://ncbi.nlm.nih.gov/pubmed/25637603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095224
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